A new review article published in Bioorganic & Medicinal Chemistry (August 2025) takes a deep look at the biological processes behind aging and outlines the most promising strategies to slow it down and extend healthy years of life.
Main anti-aging measures identified
The article “Aging and anti-aging strategies: A review of past and future therapeutics” offers an in-depth examination of aging mechanisms and promising therapeutic strategies aimed at extending both lifespan and healthspan:
Senolytics
Drugs that selectively eliminate senescent (“zombie”) cells, which accumulate with age and drive inflammation and tissue dysfunction.
NAD⁺ Boosting
Restoring levels of the coenzyme NAD⁺, vital for cellular energy and DNA repair, through precursors like NMN or NR and lifestyle interventions.
Antioxidants & Anti-inflammatories
Targeting oxidative stress and chronic inflammation, both major contributors to age-related decline.
Proteostasis restoration
Improving the balance of protein production, folding and clearance in cells, which breaks down with age and is linked to neurodegenerative diseases.
Telomerase activation
Protecting or extending telomeres – the “caps” at the end of chromosomes – to support healthier cell division and delay cellular aging.
Why It Matters
According to the authors, combining these interventions could help not only to extend lifespan but also to ensure a longer healthspan – the number of years lived in good health. While many of these approaches are still being researched, they represent the most advanced frontier in the science of longevity.
You can read the complete article here.
