Skip to content Skip to footer


Cortisol is a steroid hormone produced by the adrenal glands, which are located on top of the kidneys. This hormone is often referred to as the “stress hormone” because it is released in response to stress and low blood glucose concentration.

It plays a significant role in various body functions, including metabolism regulation, immune response, and the body’s stress response.

What is cortisol?

Cortisol is a glucocorticoid hormone synthesized from cholesterol in the adrenal cortex. It is released into the bloodstream and transported throughout the body, where it can act on different tissues to modulate a range of physiological processes.

Cortisol has a chemical structure classified as a corticosteroid, featuring 21 carbon atoms. It is derived from cholesterol and belongs to a class of hormones called glucocorticoids, which affect carbohydrate metabolism.

Functions of cortisol

Metabolic regulation

Cortisol plays a critical role in the regulation of metabolism. It helps to increase blood sugar through gluconeogenesis, the process by which the liver produces glucose from non-carbohydrate sources. Additionally, cortisol aids in fat, protein, and carbohydrate metabolism, providing the body with the energy needed to respond to stress.

Immune response

Cortisol has potent anti-inflammatory and immunosuppressive properties. It regulates the immune response by inhibiting the production of inflammatory cytokines and reducing the activity of immune cells. This modulation helps prevent excessive inflammation that can damage tissues and organs.

Stress response

One of cortisol’s primary functions is managing the body’s response to stress. During stressful situations, cortisol levels increase, providing the body with the necessary energy and resources to handle the stressor. It enhances the brain’s use of glucose and increases the availability of substances that repair tissues.

How is cortisol regulated?

Hypothalamic-Pituitary-Adrenal (HPA) axis

The production and release of cortisol are regulated by the hypothalamic-pituitary-adrenal (HPA) axis. When the body perceives stress, the hypothalamus releases corticotropin-releasing hormone (CRH), which signals the pituitary gland to release adrenocorticotropic hormone (ACTH). ACTH then stimulates the adrenal glands to produce and secrete cortisol.

Feedback mechanism

Cortisol levels are controlled through a feedback mechanism. High levels of cortisol in the blood signal the hypothalamus and pituitary gland to reduce CRH and ACTH production, respectively. This feedback loop ensures that cortisol levels remain balanced and do not become excessively high or low.

Effects of imbalanced cortisol levels

High cortisol levels

Prolonged elevated cortisol levels, known as hypercortisolism or Cushing’s syndrome, can lead to several health issues. Symptoms may include weight gain, particularly around the abdomen and face, high blood pressure, muscle weakness, mood swings, and osteoporosis. Chronic stress is a common cause of sustained high cortisol levels.

Low cortisol levels

Low cortisol levels, known as hypocortisolism or Addison’s disease, can also result in significant health problems. Symptoms of Addison’s disease include fatigue, muscle weakness, weight loss, low blood pressure, and hyperpigmentation of the skin. It occurs when the adrenal glands do not produce sufficient cortisol, often due to autoimmune disorders or adrenal gland damage.

Managing cortisol levels

Lifestyle changes

Managing stress through lifestyle changes can help regulate cortisol levels. Practices such as regular physical activity, sufficient sleep, healthy eating, and stress-reduction techniques (e.g., meditation, yoga) are effective ways to maintain balanced cortisol levels.

Medical treatments

In cases of severe cortisol imbalance, medical treatments may be necessary. For high cortisol levels, medications that inhibit cortisol production or surgery to remove a cortisol-secreting tumor may be prescribed. For low cortisol levels, corticosteroid replacement therapy is commonly used.

Leave a comment