A new study in the International Journal of Biological Macromolecules has revealed exciting anti-aging properties from a natural compound found in Coix seed, a traditional Chinese medicinal plant also known as Job’s tears.
What researchers discovered about coix seed
Scientists isolated a purified polysaccharide called CP1 from coix seed, after fermentation with lactic acid bacteria. This natural sugar-based molecule showed remarkable results across different models:
- Antioxidant power: CP1 neutralized harmful free radicals by more than 65%, protecting cells from oxidative stress;
- Longer life in worms: in experiments with Caenorhabditis elegans, CP1 extended lifespan by 3–5 days and boosted survival rates under stress by 78%;
- Youthful cells and tissues: CP1 reduced signs of cellular aging in zebrafish and lowered DNA damage in human skin fibroblasts.
On a molecular level, CP1 seems to work by activating the p-AMPK/RICTOR/CREB3 pathway, a mechanism linked to energy balance and cellular repair.
Why it matters for healthy aging
Oxidative stress and DNA damage are two key drivers of aging. By helping cells defend against these processes, CP1 may support healthier aging and protection against age-related decline.
While the research is still in early stages, the findings suggest that fermented Coix seed extracts could become candidates for future anti-aging therapies or supplements.
Where to find Job’s tears
Coix seed (Job’s tears) is widely consumed in Asia as both food and herbal medicine. You can find it:
- In Asian supermarkets: often sold as dried grains for cooking in soups, teas or porridges;
- In health food stores: sometimes available as Job’s tears or Chinese pearl barley.
- As supplements: certain brands already offer Coix seed extract in capsule or powder form.
This study reinforces the value of traditional foods and natural compounds in modern longevity science. Fermentation not only enhances flavor and digestibility but may also unlock powerful bioactive molecules that support health and resilience as we age.
